Antinociceptive and Anti-Inflammatory Activities of the Sesame Oil and Sesamin

نویسندگان

  • Érika Maria Henriques Monteiro
  • Lucas Apolinário Chibli
  • Célia Hitomi Yamamoto
  • Mônica Cecília Santana Pereira
  • Fernanda Maria Pinto Vilela
  • Mírian Pereira Rodarte
  • Míriam Aparecida de Oliveira Pinto
  • Maria da Penha Henriques do Amaral
  • Marcelo Silva Silvério
  • Ana Lúcia Santos de Matos Araújo
  • Aílson da Luz André de Araújo
  • Glauciemar Del-Vechio-Vieira
  • Orlando Vieira de Sousa
چکیده

Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Roasting Process on Sesamin and Sesamol Contents of Sesame (Sesamum indicum L.) from Different Parts of Iran

Background and objectives: Sesame (Sesamum indicum L.) seeds have been a well-known oil crop in the world for many centuries. Lignans are functionally important compartments of sesame. Sesamin and sesamol are the main sesame lignans, which have recently shown various activities with health benefits, like anti-oxidative, anti-proliferative, anti-atherosclerotic, anti-in...

متن کامل

In vivo analgesic and anti-inflammatory effects of the essential oil from Artemisia sieberi fruit

Background and objectives: Drugs with analgesic properties such as opioids and NSAIDs have not been effective in all cases, because of their low potency and side effects. As a result, looking for other alternatives is necessary. Plants are important sources of new phytochemicals that possess significant therapeutic effects. Regarding the traditional use of Artemisia sieberi...

متن کامل

Open, sesame! The gateway to mitigate hepatic injury using sesamin.

The magic phrase “Open, sesame!” from the famous Arabian story, Ali Baba and the Forty Thieves, is familiar and popular worldwide, and may have originated from the sudden opening of the sesame capsule to spread seeds. Sesame seeds and their oil have been utilized as an important foodstuff for thousands of years. They are regarded as healthy food and widely used for their distinct taste and flav...

متن کامل

Anti-inflammatory activity and chemical composition of Pycnocycla bashagardiana fruit’s essential oil in animal models

Objective(s): Pycnocycla bashagardiana is an endemic species found only in Iran. Due to the presence of myristicin as the major component of the fruit’s oil we were prompted to assess the antinociceptive and anti-inflammatory properties of P. bashagardiana fruit’s essential oil (PBFEO). Materials and Methods: The analgesic activities of PBFEO (100, 200, and 400 mg/kg, IP) were studied by hot-pl...

متن کامل

Sesame Seed Lignans Diversity, Human Metabolism and Bioactivities

Moazzami, A.A. 2006. Sesame Seed Lignans Diversity, Human Metabolism and Bioactivity. Doctor’s dissertation. ISSN 1652-6880, ISBN 91-576-7147-8 Sesame seed has been an important oilseed since ancient times. It contains 25% protein and 50% oil. Sesame seed possesses many health promoting effects, some of which have been attributed to a group of compounds called lignans (sesamin, sesamolin, sesam...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 6  شماره 

صفحات  -

تاریخ انتشار 2014